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. 2015 Mar 18;9:89. doi: 10.3389/fncel.2015.00089

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Copyright © 2015 Williams and Hablitz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Frequency and area of spontaneous depolarizing GABAergic potentials in L2/3 FS-BCs increase with I_h inhibition. (A) Representative trace of a spontaneous depolarizing GABAergic potential (arrow) in a L2/3 FS-BC. Specimen record also shows characteristic 4-AP induced baseline burst firing in FS-BC, which precede and follow spontaneous depolarizing GABAergic potentials. (B) Representative trace of spontaneous events following bath application of ZD 7288. (C) Summary plot demonstrates that inhibition of I_h with ZD 7288 significantly increases the frequency of spontaneous depolarizing GABAergic potentials in FS-BCs (n = 7). (D) Summary plot demonstrates that the area of spontaneous depolarizing GABAergic potentials significantly increases with inhibition of I_h (n = 7). ^∗p < 0.05.