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. 2015 Mar 18;9:89. doi: 10.3389/fncel.2015.00089

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Copyright © 2015 Williams and Hablitz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of I_h inhibition with ZD 7288 on magnitude of evoked depolarizing GABAergic potentials in MCs. (A) Superimposition of representative responses of a L2/3 MC to a 250 pA hyperpolarizing current pulse. Characteristic sag (arrow) and rebound responses (arrow head) observed under control conditions (black) were inhibited following application of ZD 7288 (red). (B) Representative responses of evoked depolarizing GABAergic potentials in a L2/3 MC before (black) and after (red) bath application of ZD 7288. (C) Summary graph showing a significant increase in the amplitude of evoked depolarizing GABAergic potentials in MCs upon inhibition of I_h. (D) Summary plot indicating that ZD 7288 significantly increases the area of evoked depolarizing GABAergic potential responses in MCs (n = 7). ^∗p < 0.05.