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. 2015 Mar 14;16(1):37. doi: 10.1186/s12931-015-0201-y

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© Wang et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Cigarette smoke (CS) exposure prior to influenza virus infection results in augmented lung inflammation. Mice were exposed to room air (RA) or CS for 3 months and then infected with influenza virus or vehicle control. They were sacrificed and evaluated on day 7 after infection. Representative haematoxylin and eosin stained lung sections from (A) RA-exposed mice, (B) CS-exposed mice, (C) RA-exposed mice with influenza virus infection and (D) CS-exposed mice with influenza virus infection are shown. Scale bar, 100 μm; Original magnification, ×100.