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. 2015 Mar 4;2015:458123. doi: 10.1155/2015/458123

Figure 5.

Figure 5

Aging weakens depression of corticostriatal responses induced by group I mGluR activation. (a) The mean time course of alterations in corticostriatal field responses induced by the group I mGluR agonist DHPG (100 µM) in striatal slices from mice of different ages (n = 8-9 per group). (b) The magnitudes of initial (averaged through minutes 5–20 after DHPG, open bars) and long-term (averaged through minutes 55–70 after DHPG, filled bars) depression in the striatal slices from mice of four age groups. Significant decrease of corticostriatal responses compared to the baseline is marked by asterisks: * P < 0.05, ** P < 0.01, paired t-test.