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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2014 Sep 30;0(8):673–683. doi: 10.1002/ajmg.b.32272

Table I.

Variants significantly associated with alcohol dependence phenotypes.

Position R A dbSNP id Gene Location p FDR ph MAF Hh Hl Lh Ll
100017594 G A rs145341314 ADH5/4 Intergenic 0.0026 S 0.323 0.700 0.573 0.094 0.069
100036065 T C - ADH5/4 Intergenic 0.0026 S 0.294 0.667 0.565 0.063 0.055
100037140 T C rs187939013 ADH5/4 Intergenic 0.0410 S 0.336 0.667 0.573 0.094 0.123
100051161 C A rs7692974 ADH4 Intron7/6 0.0234 S 0.334 0.700 0.565 0.094 0.123
100057074 G A - ADH4 Intron6/5 0.0029 S 0.028 0.100 0.015 0.000 0.000
100058770 C A rs10026860 ADH4 Intron5/4 0.0246 S 0.335 0.700 0.565 0.094 0.123
100061531 C T rs6840413 ADH4 Intron4/3 0.0234 S 0.334 0.700 0.565 0.094 0.123
100062338 C T rs35882815 ADH4 Intron4/3 0.0226 S 0.335 0.700 0.565 0.094 0.123
100066287 C T rs4148884 ADH4/6 Intergenic 0.0175 S 0.326 0.700 0.565 0.063 0.103
100067337 A G rs2226896 ADH4/6 Intergenic 0.0026 S 0.306 0.700 0.551 0.063 0.048
100068799 T A - ADH4/6 Intergenic 0.0082 S 0.278 0.667 0.507 0.063 0.041
100069458 A G rs10022174 ADH4/6 Intergenic 0.0125 S 0.326 0.700 0.558 0.063 0.103
100070816 A G rs12649136 ADH4/6 Intergenic 0.0026 S 0.306 0.700 0.551 0.063 0.048
100072567 C T rs2156731 ADH4/6 Intergenic 0.0026 S 0.309 0.700 0.565 0.063 0.055
100075175 C T rs57058570 ADH4/6 Intergenic 0.0026 S 0.308 0.700 0.558 0.063 0.048
100076962 T C rs72679827 ADH4/6 Intergenic 0.0026 S 0.308 0.700 0.558 0.063 0.048
100085463 C T rs61681818 ADH4/6 Intergenic 0.0026 S 0.311 0.700 0.565 0.063 0.055
100088567 T C rs12499210 ADH4/6 Intergenic 0.0026 S 0.309 0.700 0.558 0.063 0.048
100094364 C T rs36139400 ADH4/6 Intergenic 0.0026 S 0.311 0.700 0.565 0.063 0.055
100102320 C G rs12504491 ADH4/6 Intergenic 0.0026 S 0.311 0.700 0.565 0.063 0.055
100104829 C T rs55926943 ADH4/6 Intergenic 0.0026 S 0.310 0.700 0.565 0.063 0.048
100108104 C T rs58964688 ADH4/6 Intergenic 0.0029 S 0.311 0.700 0.565 0.063 0.062
100115380 C T rs138293424 ADH4/6 Intergenic 0.0026 S 0.311 0.700 0.558 0.063 0.055
100116074 G A rs12502056 ADH4/6 Intergenic 0.0026 S 0.308 0.700 0.551 0.063 0.048
100120992 A T rs12499710 ADH4/6 Intergenic 0.0026 S 0.310 0.700 0.558 0.063 0.048
100125868 G A rs12507078 ADH6 Intron8 0.0026 S 0.309 0.700 0.558 0.063 0.048
100138736 A C rs7692358 ADH6 Intron1 0.0088 S 0.316 0.700 0.565 0.063 0.075
100139366 C T rs4699734 ADH6 Intron1 0.0026 S 0.308 0.700 0.558 0.063 0.055
100145441 G A rs7375388 ADH6/1A Intergenic 0.0026 S 0.318 0.683 0.565 0.094 0.055
100145719 G A rs55641355/rs7375429 ADH6/1A Intergenic 0.0026 S 0.308 0.700 0.551 0.063 0.055
100147453 G A rs58584512 ADH6/1A Intergenic 0.0026 S 0.309 0.700 0.565 0.063 0.055
100148946 C T rs143770077 ADH6/1A Intergenic 0.0026 S 0.309 0.700 0.565 0.063 0.055
100151262 T G rs7669335 ADH6/1A Intergenic 0.0030 S 0.311 0.700 0.565 0.063 0.055
100152009 T G rs148671455 ADH6/1A Intergenic 0.0026 S 0.308 0.700 0.565 0.063 0.055
100152864* G A rs6813954 ADH6/1A Intergenic 0.0458 M 0.370 0.011 0.065 0.641 0.796
100157010 A G rs58660705 ADH6/1A Intergenic 0.0026 S 0.309 0.700 0.565 0.063 0.055
100157132 G C rs60468511 ADH6/1A Intergenic 0.0026 S 0.308 0.700 0.558 0.063 0.055
100157669 C T rs7654607 ADH6/1A Intergenic 0.0026 S 0.309 0.700 0.565 0.063 0.055
100157771 G T rs60345995 ADH6/1A Intergenic 0.0026 S 0.308 0.700 0.551 0.063 0.055
100161162 T C rs12501204 ADH6/1A Intergenic 0.0026 S 0.310 0.700 0.565 0.063 0.055
100164269 T C rs149215710 ADH6/1A Intergenic 0.0036 S 0.310 0.700 0.565 0.063 0.055
100168980 C G rs4699381 ADH6/1A Intergenic 0.0026 S 0.309 0.700 0.565 0.063 0.055
100169797 G C rs72679867 ADH6/1A Intergenic 0.0026 S 0.308 0.700 0.565 0.063 0.055
100171239 C T rs2010612 ADH6/1A Intergenic 0.0026 S 0.309 0.700 0.565 0.063 0.055
100173158 C T rs12504443 ADH6/1A Intergenic 0.0026 S 0.308 0.700 0.558 0.063 0.048
100181911 G A rs113289860 ADH6/1A Intergenic 0.0026 S 0.310 0.700 0.551 0.063 0.055
100181934 T C rs72679874 ADH6/1A Intergenic 0.0026 S 0.309 0.700 0.551 0.063 0.055
100183973 A G rs7663369 ADH6/1A Intergenic 0.0026 S 0.313 0.700 0.565 0.063 0.055
100185431 G A rs12506882 ADH6/1A Intergenic 0.0026 S 0.312 0.700 0.565 0.063 0.055
100186063 C T rs58827689 ADH6/1A Intergenic 0.0026 S 0.312 0.700 0.565 0.063 0.055
100188396 T C rs17028765 ADH6/1A Intergenic 0.0329 S 0.296 0.667 0.544 0.063 0.055
100195815 G T rs12512110 ADH6/1A Intergenic 0.0326 S 0.295 0.667 0.536 0.063 0.055
100200153 C T rs28364333 ADH1A Intron8 0.0329 S 0.296 0.667 0.544 0.063 0.055
100202705 G T rs12504321 ADH1A Intron6 0.0270 S 0.296 0.667 0.544 0.063 0.055
100203037 C T rs12504365 ADH1A Intron6/3UTR 0.0428 S 0.297 0.667 0.544 0.063 0.062
100203156 A G rs12512053 ADH1A Intron6/3UTR 0.0439 S 0.296 0.667 0.544 0.063 0.055
100203176 T C rs12508502 ADH1A Intron6/3UTR 0.0439 S 0.296 0.667 0.544 0.063 0.055
100203447 A C rs2276332 ADH1A Intron6/Exon2 0.0432 S 0.296 0.667 0.544 0.063 0.055
100206912 T C rs28364304 ADH1A Intron3 0.0326 S 0.296 0.667 0.544 0.063 0.055
100211399 T C rs3805325 ADH1A Intron1 0.0269 S 0.297 0.667 0.544 0.063 0.055
100215587 C T rs72679893 ADH1A Intron1 0.0134 S 0.302 0.667 0.536 0.094 0.055
100219582 G A rs12505816 ADH1A Intron1 0.0141 S 0.300 0.667 0.529 0.094 0.055
100223957 A C rs111797757 ADH1A Intron1 0.0134 S 0.301 0.667 0.536 0.094 0.055
100225336 G A rs56948765 ADH1A Intron1 0.0192 S 0.303 0.667 0.544 0.094 0.055
100226777 A C rs73832758 ADH1A Intron1 0.0193 S 0.302 0.667 0.536 0.094 0.055
100227288 G C rs28914794 ADH1A Intron1 0.0192 S 0.302 0.667 0.544 0.094 0.055
100228945 T C rs17033 ADH1B 3UTR 0.0192 S 0.299 0.667 0.529 0.094 0.055
100233126 C T rs28914775 ADH1B Intron6/7 0.0193 S 0.301 0.667 0.536 0.094 0.055
100233892 C T rs28914770 ADH1B Intron6/7 0.0175 S 0.302 0.667 0.544 0.094 0.055
100253409 C T rs1497372 ADH1C Downstream 0.0185 D 0.230 0.335 0.214 0.254 0.104
0.0038 S 0.230 0.450 0.203 0.250 0.116
100294612 A C rs1846039 ADH1C Upstream 0.0491 M 0.459 0.587 0.565 0.609 0.432
100296248 C T rs10030511 ADH1C Upstream 0.0491 M 0.459 0.587 0.565 0.609 0.432
100296684 T C rs35208813 ADH1C Upstream 0.0491 M 0.460 0.587 0.565 0.609 0.432
100296748 T C rs35796885 ADH1C Upstream 0.0491 M 0.460 0.587 0.565 0.609 0.432
100299450 G A rs9997820 ADH1C Upstream 0.0491 M 0.459 0.587 0.565 0.609 0.432
100299641 C A rs1908962 ADH1C Upstream 0.0458 M 0.490 0.565 0.548 0.531 0.352
100299978 T C rs1837932 ADH1C Upstream 0.0491 M 0.459 0.587 0.565 0.609 0.432
100304921* C T rs2654841 ADH7 Downstream 0.0491 M 0.459 0.413 0.436 0.391 0.568
100306839* G A rs2654842 ADH7 Downstream 0.0475 M 0.462 0.413 0.436 0.391 0.568
100310907* C T rs284782 ADH7 Downstream 0.0458 M 0.431 0.413 0.419 0.328 0.500
100312545* G T rs2654843 ADH7 Downstream 0.0458 M 0.464 0.413 0.436 0.391 0.568
100313611* G A rs284783 ADH7 Downstream 0.0458 M 0.432 0.413 0.419 0.328 0.500
100320597* A G rs2851015 ADH7 Downstream 0.0458 M 0.463 0.413 0.436 0.391 0.580
100322445* T C rs991316 ADH7 Downstream 0.0458 M 0.370 0.250 0.307 0.375 0.568
100322497* C G rs1442491 ADH7 Downstream 0.0458 M 0.370 0.250 0.307 0.375 0.568
100322498* C A rs991315 ADH7 Downstream 0.0458 M 0.370 0.250 0.307 0.375 0.568
100326449* T C rs72681947 ADH7 Downstream 0.0326 S 0.094 0.000 0.015 0.125 0.171
100327104* T A rs72681948 ADH7 Downstream 0.0326 S 0.094 0.000 0.015 0.125 0.171
100334449* T A rs17588403 ADH7 Intron8 0.0270 S 0.095 0.000 0.022 0.125 0.171
112241720+ G A rs190914158 ALDH2 Exon11/12 0.0090 D 0.023 0.079 0.012 0.007 0.000

R: reference allele. A: alternative allele. pFDR: FDR-adjusted p-value.

ph: phenotype (S: dependence drinking symptoms; D: dependence diagnosis; M: max-drink).

MAF: alternative allele frequency.

Hh, Hl,Lh,Ll: alternative allele frequency of subset samples (H/L: high/low NA heritage, h/l: high/low values of respective phenotype).

*

Negative association.

+

Variant is on chromosome 12; all other are on chromosome 4.