Table 1. Structure-activity analysis of symmetrical DMTU analogs.
Inhibitor | Structure | UT-A1 IC50 (mM) | UT-B IC50 (mM) |
---|---|---|---|
1 | 6.6 ± 0.4 | 3.9 ± 0.6 | |
2 | >25 | >25 | |
3 | 22 ± 1 | 14 ± 2 | |
4 | >25 | 17 ± 2 | |
5 | >25 | >25 | |
6 | >15 | 13 ± 2 | |
7 | >25 | >25 | |
8 | >25 | >25 |
Inhibitor | Structure | UT-A1 IC50 (mM) | UT-B IC50 (mM) |
---|---|---|---|
1 | 6.6 ± 0.4 | 3.9 ± 0.6 | |
2 | >25 | >25 | |
3 | 22 ± 1 | 14 ± 2 | |
4 | >25 | 17 ± 2 | |
5 | >25 | >25 | |
6 | >15 | 13 ± 2 | |
7 | >25 | >25 | |
8 | >25 | >25 |