. Author manuscript; available in PMC: 2015 Mar 18.

Published in final edited form as: Nat Neurosci. 2014 Jan 28;17(2):175–182. doi: 10.1038/nn.3619

Table 1.

Receptors and channels that mediate itch transduction in sensory neurons

	Receptor	Agonists	Type
Peripheral	Histamine receptor 1 (ref. 68)	Histamine	GPCR
	MrgprA3 (ref. 15)	Chloroquine	GPCR
	MrgprCll (MrgprX1 in humans)¹⁵	BAM, SLIGRL	GPCR
	MrgprD¹⁶	β-Alanine	GPCR
	Endothelin-1 (refs. 69-71)	Endothelin	GPCR
	5-HT receptors 1-7 (ref. 72)	Serotonin, 12(S)-HPETE	GPCR
	Protease-activated receptor 2 (refs. 24,26,73-75)	Tryptase, trypsin, SLIGRL, SLIGR, LIGRLO	GPCR
	TRL3 (ref. 29)	Poly(I:C)	Cytokine
	TLR7 (ref. 28)	Imiquimod	Cytokine
	TSLPR (in complex with IL-7Ra)¹²	TSLP	Cytokine
	IL-31R⁶⁶	IL-31	Cytokine
	TRPA1 (ref. 14)	Allyl isothiocyanate, cinnamaldehyde (reviewed in ref. 76)	Ion channel
	TRPV1 (refs. 9,10)	Capsaicin (reviewed in ref. 77)	Ion channel
Central	GRPR⁴⁶,⁴⁷	GRP	GPCR
	Npra⁴⁸	BMP (NPPB)	Receptor GC
	MOR1D⁵⁷	Opioids	GPCR