Fig. 1.

Changes in baroreflex sensitivity and heart rate variability during developing obesity and responses to baroreflex activation therapy and bilateral renal denervation during established obesity. Control (C), recovery (Rec). During days 4–31, obesity hypertension was induced by feeding dogs a high-fat diet. During this time, mean arterial pressure and heart rate increased from 100±2 to 117±3 mm Hg and from 86±3 to 130±4 bpm, respectively, along with an increase in body weight of approximately 50 %. After day 31, dietary fat was minimal, and there were no further change in body weight throughout the remainder of the study