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Tumor Heterogeneity. CSCs located inside the tumor mass exist predominantly in the MET state in which they are highly proliferative and express ALDH (ALDH+), in contrast at the tumor invasive front are located with EMT CSCs which are characterized as CD24−CD44+ and are highly invasive, and mediates tumor invastion and metastasis. The intermediate CSCs (CD24−CD44+ALDH+) also reside inside the tumor mass, and they are highly proliferative with invasive potential
