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. Author manuscript; available in PMC: 2016 Feb 15.
Published in final edited form as: J Immunol. 2015 Jan 9;194(4):1565–1579. doi: 10.4049/jimmunol.1401162

Figure 3.

Figure 3

Analysis of methylation at individual CpGs in CD4 T cells. (A) Hierachical clustering of individual CpG methylation in CD4 T cells. Samples are labeled with cell subset, donor identifier (numerical value), and time point following activation (0 or 48 h). (B) Differential methylation between memory and naïve CD4 T cells. (C) Cytokine expression by naïve and memory cells activated for 48 h. Data are representative of 6 donors (symbols represent different donors, red lines represent average signal). (D) Promoter methylation of IFNγ for naïve (open circles, dashed line) and memory (filled squares, solid line) CD4 T cells. The filled diamond marks the TSS and the arrow indicates directionality of transcription. Data are representative of 2 donors.