Table 2.

Mitochondrial respiratory function after 14 weeks of treatment

	Untreated		DHA treated
	Sham	Heart failure	Sham	Heart failure
SSM
Glutamate + Malate
State 3	179±14	183±12	201±10	183±8
State 4	30.1±1.7	30.5±2.0	32.3±2.6	29.9±2.9
Respiratory control ratio	5.9±0.3	6.2±0.4	6.7±0.6	6.7±0.4
ADP:O	2.26 ±0.09	2.15±0.07	2.08±0.13	2.20±0.08
Palmitoylcarnitine
State 3	184±13	181±8	251±11^	193±7*
State 4	50.7±3.7	51.5±2.8	57.1±4.7	49.3±3.9
Respiratory control ratio	3.8±0.3	3.6±0.1	5.0±0.7	4.2±0.3
ADP:O	2.12±0.05	2.19±0.04	2.13±0.05	2.28±0.05
Succinate + Rotenone
State 3	286±15	267±15	327±13	304±10
State 4	114±4	103±7	120±5	114±5
Respiratory control ratio	2.5±0.1	2.7±0.1	2.7±0.1	2.7±0.1
ADP:O	1.33±0.04	1.40±0.11	1.28±0.04	1.47±0.06
IFM
Glutamate + Malate
State 3	198±15	194±12	215±9	199±10
State 4	36.2±2.9	42.2±2.3	42.1±5.1	32.7±2.1#
Respiratory control ratio	5.7±0.4	4.7±0.3	5.9±0.6	6.4±0.4#
ADP:O	2.71±0.21	2.57±0.16	2.25±0.11	2.52±0.08
Palmitoylcarnitine
State 3	225±17	224±9	261±10	231±10
State 4	70.5±5.8	76.4±4.3	68.2±4.6	61.8±3.4#
Respiratory control ratio	3.4±0.3	3.0±0.1	4.1±0.3^	3.8±0.2#
ADP:O	2.27±0.09	2.30±0.06	2.48±0.12	2.47±0.07
Succinate + Rotenone
State 3	397±15	426±20	440±17	438±13
State 4	153±5	154±7	167±14	157±5
Respiratory control ratio	2.6±0.1	2.8±0.1	2.7±0.2	2.8±0.1
ADP:O	1.44±0.07	1.27±0.04	1.43±0.05	1.31±0.05

^*P <0.05 Heart failure vs. respective sham.

^#P <0.05 DHA treatment vs. standard diet in heart failure.

^{^}P <0.05 DHA treatment vs. standard diet in shams

Groups sizes were 15 and 20 for the untreated sham and heart failure groups, respectfully, and 14 and 20 for the DHA treated sham and heart failure groups, respectfully