Table 3.
The associations of KRAS and BRAF mutations and MSI to the risk of recurrence and dissemination in patients with colon cancer
| Disease stage II and III | Disseminated¥ | Non disseminatedβ | Odds ratio (95% Confidence interval) | P | ||||
|---|---|---|---|---|---|---|---|---|
| Recurrence | No recurrence | Odds ratio (95% Confidence interval) | P | |||||
| n | 42 | 53 | 68 | 53 | ||||
| KRAS | ||||||||
| Mutation | 18 | 14 | 2.09 (0.88-4.96) | 0.092 | 34 | 14 | 2.75 (1.28-6.04) | 0.009 |
| Wild type | 24 | 39 | 34 | 39 | ||||
| BRAF | ||||||||
| Mutation | 6 | 18 | 0.32 (0.16-0.91) | 0.034 | 10 | 18 | 0.34 (0.14-0.81) | 0.013 |
| Wild type | 36 | 35 | 58 | 35 | ||||
| MSI | ||||||||
| MSI | 5 | 17 | 0.29 (0.10-0.86) | 0.027 | 7 | 17 | 0.24 (0.09-0.64) | 0.005 |
| MSS | 37 | 36 | 61 | 36 | ||||
| MSS only | ||||||||
| KRAS | ||||||||
| Mutation | 18 | 13 | 0.95 (0.35-2.58) | 0.279 | 33 | 13 | 2.08 (0.89-4.86) | 0.087 |
| Wild type | 19 | 23 | 28 | 23 | ||||
| BRAF | ||||||||
| Mutation | 2 | 5 | 0.35 (0.06-1.96) | 0.261 | 5 | 5 | 0.55 (0.15-2.06) | 0.492 |
| Wild type | 35 | 31 | 56 | 31 | ||||
| KRAS wild type only | ||||||||
| MSI | ||||||||
| MSI | 5 | 16 | 0.38 (0.12-1.22) | 0.168 | 6 | 16 | 0.31 (0.10-0.91) | 0.041 |
| MSS | 19 | 23 | 28 | 23 | ||||
| BRAF | ||||||||
| Mutation | 6 | 18 | 0.39 (0.13-1.19) | 0.115 | 10 | 18 | 0.49 (0.18-1.28) | 0.142 |
| Wild type | 18 | 21 | 24 | 21 | ||||
| BRAF wild type only | ||||||||
| MSI | ||||||||
| MSI | 1 | 4 | 0.22 (0.02-2.09) | 0.198 | 2 | 4 | 0.28 (0.04-1.60) | 0.194 |
| MSS | 35 | 31 | 56 | 31 | ||||
| KRAS | ||||||||
| Mutation | 18 | 14 | 1.50 (0.59-3.84) | 0.397 | 34 | 14 | 2.13 (0.90-4.99) | 0.082 |
| Wild type | 18 | 21 | 24 | 21 | ||||
| MSI and BRAF* | ||||||||
| BRAF wild type + MSS | 35 | 31 | 3.55 (1.33-9.44) | 0.013 | 56 | 31 | 3.31 (1.45-7.59) | 0.004 |
| BRAF mutation + MSS | 2 | 5 | 0.48 (0.09-2.61) | 0.459 | 5 | 5 | 0.76 (0.21-2.78) | 0.747 |
| BRAF mutation + MSI | 4 | 13 | 0.32 (0.10-1.08) | 0,050 | 5 | 13 | 0.24 (0.08-0.74) | 0.011 |
| BRAF wild type + MSI | 1 | 4 | 0.30 (0.03-2.78) | 0.379 | 2 | 4 | 0.37 (0.07-2.11) | 0.403 |
βNon-disseminated: Disease stages II and III without recurrence; ¥Disseminated: Disease stages II and III with recurrence and stage IV.
*The comparison of each subgroup is made with all other groups.