Table 2.
Top 15 differently methylated sites in weight category and the STK33 rs4929949 polymorphism; STK33 category
| Gene | Entrez gene ID | Genomic position of the probe/island (hg19) | HIL class | Genomic location of the closest TSS (hg19) | Coefficient | Raw p-value | Adjusted p-value |
|---|---|---|---|---|---|---|---|
| REM1 | 28954 | chr20_IC:30062552-30063794 | IC | 30063104 | −0,0931 | 5,76E-06 | 0,0324 |
| TERT | 7015 | chr5_HCshore:1294078–1296099; chr5_ICshore:1292899-1296102 | HC | 1295161 | −0,149 | 1,03E-05 | 0,0324 |
| DRD5 | 1816 | chr4:9782881 | ICshore | 9783257 | −0,16 | 1,13E-05 | 0,0324 |
| TRPC3 | 7222 | chr4:122853965 | HC | 122854196 | −0,25 | 1,72E-05 | 0,0324 |
| FOXD1 | 2297 | chr5:72744904 | ICshore | 72744351 | −0,115 | 1,84E-05 | 0,0324 |
| ESPNL | 339768 | chr2:239008986 | IC | 239008950 | −0,158 | 1,86E-05 | 0,0324 |
| ZFYVE9 | 9372 | chr1:52608558 | HC | 52608045 | −0,133 | 2,37E-05 | 0,0354 |
| NPY4R | 5540 | chr10:47083233 | IC | 47083533 | −0,213 | 3,25E-05 | 0,0393 |
| PKP1 | 5317 | chr1_HCshore:201252407–201253409; chr1_ICshore:201252275-201253817 | HC | 201252579 | −0,175 | 4,21E-05 | 0,0393 |
| FAM118A | 55007 | chr22:45705265 | HC | 45705080 | −0,279 | 4,32E-05 | 0,0393 |
| CEBPE | 1053 | chr14:23588162 | IC | 23588819 | −0,134 | 4,47E-05 | 0,0393 |
| CORO7 | 79585 | chr16:4465731 | ICshore | 4465897 | −0,144 | 4,50E-05 | 0,0393 |
| CHST8 | 64377 | chr19:34175481 | IC | 34175433 | −0,145 | 8,08E-05 | 0,065 |
| NAA40 | 79829 | chr11:63705946 | HC | 63706441 | 0,107 | 9,22E-05 | 0,0674 |
| CELSR1 | 9620 | chr22_HCshore:46931364–46934654; chr22_ICshore:46929131-46935234 | HC | 46933066 | −0,205 | 9,97E-05 | 0,0674 |
Abbreviations: high-density CpG island (HC), intermediate-density CpG island (IC), region of intermediate-density CpG island that borders HCs (ICshore).