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. 2015 Mar 19;16:8. doi: 10.1186/s12867-015-0038-4

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© Dean et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Ets1 is under repression by the Rb1 family. Mutation of Rb1 in primary cultures of mouse embryo fibroblasts (MEFs) led to significant (p < 0.05) induction of Ets1 mRNA, and Ets1 mRNA was further very significantly (p < 0.01) induced when all three closely related Rb1 family members (Rb1, Rbl1 and Rbl2) were mutated to generate triple knockout (TKO) MEFs. Real time PCR results normalized to actin mRNA are shown.