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Zeb1 mutation eliminates Ets1 expression in differentiating embryonic thymocytes. A-G H&E sections of embryonic day 15.5 wild-type and Zeb1(−/−) embryos showing the thymus (T). Note the decrease in thymocyte number with Zeb1 mutation. (C-J) Immunostaining showing loss of expression of Ets1 with Zeb1 mutation in differentiating thymocytes. CD3 is a T-cell marker.
