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. 2015 Mar 13;8:12. doi: 10.1186/s12920-015-0082-4

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© Li et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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MiRNA targeted the signaling pathways of upregulated genes from macrophages in ruptured atherosclerotic plaque. The data which compared macrophage in ruptured atherosclerotic plaque with in stable plaque were obtained from GEO database. SAM was used to analyze the significantly differentially expressed genes (FDR<0.05). Those genes enriched pathways and miRNA target gene pathways were clustered by DAVID based on Reactome pathway. A: Whole blood miRNAs target pathways. B: plasma miRNAs target pathways. Illustration combined the miRNA target pathways which were also involved in the coronary atherosclerosis plaque.