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. 2015 Mar 13;8:12. doi: 10.1186/s12920-015-0082-4

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© Li et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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MiRNA targeted upregulated genes of Rho GTPase signaling. MiRNA target was predicted by targetscan, Miranda and DIANAmT. The ruptured plaque microarray data were analyzed by SAM, and significantly differentially expressed genes were input into DAVID to select the hemostasis related gene. The miRNA targets and Rho GTPase related genes were integrated. A: the network of whole blood miRNAs target genes. B: the network of plasma miRNAs target genes. The names of genes were official gene symbols. MicroRNAs with red border line are the miRNAs presents in the former network target the Rho GTPase pathway. The green node represents activation of Rho GTPase GDP by GEFS. The brown node represents activation of stream effector by Rho GTPase GTP. The blue node represents inactivation of Rho GTPase GTP by GAPs through hydrolysis. The purple node represents inactivation of Rho GTpase GDP by GDIs.