Table 5. STRING v9.1 analysis of the 27 proteins deregulated only in glia exposed to AD plasma (shown in Table 4 ).
for enrichment in gene ontology biological processes. Glucose metabolism was found to be the most significant biological process, and is also highlighted in the STRING network map (Fig. 5).
| Molecular Function Enrichment GO_ID | Term | Number of Proteins | p-value | p-value FDR | p-value Bonferroni |
| GO:0003723 | RNA Binding | 17 | 1.94E-12 | 5.34E-09 | 7.51E-09 |
| GO:0044822 | Poly(A) RNA Binding | 16 | 2.75E-12 | 5.34E-09 | 1.07E-08 |
| GO:0008379 | Thioredoxin peroxidase activity | 2 | 8.88E-06 | 9.22E-03 | 3.45E-02 |
| GO:0003676 | Nucleic acid binding | 16 | 9.50E-06 | 9.22E-03 | 3.69E-02 |
| GO:0051920 | Peroxiredoxin activity | 2 | 2.95E-05 | 2.29E-02 | 1.15E-01 |
| Biological Process Enrichment GO_ID | Term | Number of Proteins | p-value | p-value FDR | p-value Bonferroni |
| GO:0006006 | Glucose metabolic process | 9 | 1.42E-12 | 1.76E-08 | 1.76E-08 |
| GO:0019318 | Hexose metabolic process | 9 | 7.28E-12 | 4.51E-08 | 9.02E-08 |
| GO:0005996 | Monosaccharide metabolic process | 9 | 3.63E-11 | 1.50E-07 | 4.49E-07 |
| GO:0046364 | Monosaccharide biosynthetic process | 6 | 2.23E-10 | 6.89E-07 | 2.75E-06 |
| GO:0016051 | Carbohydrate biosynthetic process | 7 | 7.56E-10 | 1.87E-06 | 9.35E-06 |
| GO:0006094 | Gluconeogenesis | 5 | 5.43E-09 | 1.12E-05 | 6.73E-05 |
| GO:0019319 | Hexose biosynthetic process | 5 | 9.29E-09 | 1.64E-05 | 1.15E-04 |
| GO:0042542 | Response to hydrogen peroxide | 4 | 2.30E-05 | 3.56E-02 | 2.85E-01 |
| GO:0022614 | Membrane to membrane docking | 2 | 3.13E-05 | 4.30E-02 | 3.87E-01 |
| GO:0016584 | Nucleosome positioning | 2 | 6.56E-05 | 8.12E-02 | 8.12E-01 |
| Cellular Component Enrichment GO_ID | Term | Number of Proteins | p-value | p-value FDR | p-value Bonferroni |
| GO:0070062 | Extracellular vesicular exosome | 17 | 1.04E-11 | 5.02E-09 | 1.51E-08 |
| GO:0044421 | Extracellular region part | 18 | 1.23E-09 | 4.44E-07 | 1.77E-06 |
| GO:0005576 | Extracellular region | 18 | 1.08E-07 | 3.06E-05 | 1.57E-04 |
| GO:0031988 | Membrane-bounded vesicle | 15 | 1.27E-07 | 3.06E-05 | 1.84E-04 |
| GO:0031982 | Vesicle | 15 | 1.83E-07 | 3.77E-05 | 2.64E-04 |
| GO:0043233 | Organelle lumen | 16 | 2.50E-07 | 4.32E-05 | 3.62E-04 |
| GO:0042470 | Melanosome | 5 | 2.98E-07 | 4.32E-05 | 4.32E-04 |
| GO:0005829 | Cytosol | 15 | 1.22E-06 | 1.47E-04 | 1.77E-03 |
| GO:0070013 | Intracellular organelle lumen | 13 | 5.33E-05 | 5.93E-03 | 7.71E-02 |
| GO:0031254 | Cell trailing edge | 2 | 7.00E-05 | 6.76E-03 | 1.01E-01 |
| GO:0001931 | Uropod | 2 | 7.00E-05 | 6.76E-03 | 1.01E-01 |
| GO:0030016 | Myofibril | 4 | 1.41E-04 | 1.28E-02 | 2.05E-01 |
| GO:0016323 | Basolateral plasma membrane | 4 | 1.51E-04 | 1.29E-02 | 2.19E-01 |
| GO:0043292 | Contractile fiber | 4 | 1.66E-04 | 1.33E-02 | 2.40E-01 |
| GO:0060205 | Cytoplasmic membrane-bound vesicle lumen | 3 | 2.64E-04 | 1.91E-02 | 3.82E-01 |
| GO:0031983 | Vesicle lumen | 3 | 2.64E-04 | 1.91E-02 | 3.82E-01 |
| GO:0031528 | Microvillus membrane | 2 | 2.98E-04 | 2.05E-02 | 4.31E-01 |
| GO:0016023 | Cytoplasmic membrane-bounded vesicle | 7 | 3.68E-04 | 2.42E-02 | 5.32E-01 |
| GO:0005719 | Nuclear euchromatin | 2 | 5.70E-04 | 3.43E-02 | 8.24E-01 |
| GO:0000791 | Euchromatin | 2 | 7.98E-04 | 4.62E-02 | 1.00E+00 |