Table 4. Multivariate Cox regression analysis of independent predictors associated with progression into post-enrollment EASL-CLIF ACLF from ACLF at enrollment defined by APASL alone or by both APASL and CMA but not by EASL-CLIF Consortium.
| Variables | HR | 95% CI | P value |
|---|---|---|---|
| Baseline CLIF-SOFA | 1.326 | 1.044–1.685 | 0.021 |
| Vm (ΔCLIF-SOFA) | 13.419 | 7.319–25.221 | <0.001 |
| Vm (ΔMELD-Na) | 1.047 | 1.021–1.074 | <0.001 |
| Vm (ΔTBIL) | 1.343 | 1.161–1.553 | <0.001 |
ACLF, acute-on-chronic liver failure; HR, hazard ratio; CI, confidence interval; Vm (Δ indicator) was used to represent the maximum rate of change in clinical indicators; MELD, model for end-stage liver disease; TBIL, total bilirubin; CLIF-SOFA, chronic liver failure-sequential organ failure assessment.