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. 2015 Mar 18;10(3):e0119708. doi: 10.1371/journal.pone.0119708

Fig 3. Analysis of VEGF expression level in OIR mouse eyes.

Fig 3

ELISAs revealed higher levels of VEGF expression in the eyes of mice in the saline-treated OIR group (OIR; n = 9) and metformin-treated OIR mice (+Met; n = 10) than in those of the control, reared in normoxic condition, (CTL; n = 5) and metformin-treated control (Met; n = 4) group at post natal day 17 (P17). Elevated VEGF levels in both OIR groups decreased at post natal day 21 (P21). But metformin treatment did not affect VEGF level. VEGF levels in metformin-treated OIR mice (+Met; n = 12) were not different from those in saline-treated mice (OIR; n = 12) at P17 or P21. *P < 0.05 and **P < 0.01 compared to metformin-treated CTL (Met; n = 4). (Mann-Whitney U test).