Table 1. Summary of the reactions and parameters involved in the lumped AA and LA metabolism under investigation.
No. | Reaction | Control enzyme | Parameter name |
---|---|---|---|
1 | AA → 5(S)-HETE | 5-LOX, FLAP | k 1 |
2 | AA → 15(S)-HETE | 15-LOX | k 2 |
3 | AA → 11,12-DiHETrE | CYP, sEH | k 3 |
4 | AA → 14,15-DiHETrE | CYP, sEH | k 4 |
5 | LA → 9(S)-HODE | 15-LOX | k 5 |
6 | LA → 9,10-DiHOME | CYP, sEH | k 6 |
7 | LA → 13(S)-HODE | 15-LOX | k 7 |
8 | 5(S)-HETE→ | k 8 | |
9 | 15(S)-HETE → | k 9 | |
10 | 11,12-DiHETrE → | k 10 | |
11 | 14,15-DiHETrE → | k 11 | |
12 | 9(S)-HODE → | k 12 | |
13 | 9,10-DiHOME → | k 13 | |
14 | 13(S)-HODE → | k 14 |