Fig 3. Effect of graded concentrations of etifoxine on the conversion of tritiated pregnenolone ([3H]Δ5P) into 17-hydroxypregnenolone (17OH-Δ5P), dehydroepiandrosterone (DHEA), progesterone (P), dihydroprogesterone (DHP) and tetrahydroprogesterone (THP) by frog hypothalamic explants (duration of the incubation: 2h).
The values were calculated from the areas under the peaks in chromatograms similar to those presented in Fig. 1. Results are expressed as percentages of the amount of each steroid formed in the absence of etifoxine. Values are the mean (± SEM) of four independent experiments. *p<0.05; **p<0.01; ***p<0.001; ns, not statistically different from control (C).