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. 2015 Mar 18;10(3):e0120473. doi: 10.1371/journal.pone.0120473

Fig 5. Effects of etifoxine (3x10-6 M) in the absence or presence of the TSPO antagonist PK11195 (3x10-5 M), the central-type benzodiazepine receptor antagonist flumazenil (3x10-5 M) or the GABAA receptor antagonist bicuculline (3x10-5 M) on the conversion of tritiated pregnenolone ([3H]Δ5P) into 17-hydroxypregnenolone (17OH-Δ5P), dehydroepiandrosterone (DHEA), progesterone (P) and tetrahydroprogesterone (THP) by frog hypothalamic explants.

Fig 5

The values were obtained from experiments similar to those presented in Fig. 1. Results are expressed as percentages of the amount of each steroid formed in the absence of drugs. Values are the mean (± SEM) of four independent experiments. *p<0.05; **p<0.01; ***p<0.001 compared to respective control values; NS, not statistically different from control; ns, not statistically different from etifoxine-stimulated level (one-way ANOVA followed by a post hoc Student-Newman-Keul’s test).