Fig 6. Effects of etifoxine (10-6 M) in the absence or presence of triakontatetraneuropeptide (TTN), a specific TSPO agonist (3x10-8 M), on the conversion of tritiated pregnenolone ([3H]Δ5P) into 17-hydroxypregnenolone (17OH-Δ5P), dehydroepiandrosterone (DHEA), progesterone (P) and tetrahydroprogesterone (THP) by frog hypothalamic explants.
The values were obtained from experiments similar to those presented in Fig. 1. Results are expressed as percentages of the amount of each steroid formed in the absence of drugs. Each value is the mean (± SEM) of four independent experiments. **p<0.01, ***p<0.001 vs control; ##p<0.01, ###p<0.001 vs etifoxine alone; §§ p<0.01, §§§ p<0.001 vs TTN alone (one-way ANOVA followed by a post hoc Student-Newman-Keul’s test).