Fig 3. Regression of Ramos and Granta xenografts in athymic mice after either ¹⁷⁷Lu- or ⁹⁰Y-PRIT.

Mice were injected with 1.4 nmol of 1F5-SA or HB8181-SA, together with 400 μg of HB8181. Circulating MAb-SA was cleared by administration of 5.8 nmol of NAGB after 20 hours, followed by 15–37 MBq of either ¹⁷⁷Lu- or ⁹⁰Y-labeled DOTA-biotin (2.4 nmol) 4 hours later. Ten xenograft mice per tumor model served as control group (PBS only). The curves were truncated at the time of euthanasia of the first mouse in each treatment group (mm³ ± SD; n = 10).