Fig 5. Radiation-induced toxicity in non-xenografted mice after treatment with 37 MBq of ¹⁷⁷Lu- or ⁹⁰Y-PRIT.

1F5-SA (300 μg) was co-injected with 400 μg of HB8181, followed 20 hours later by 50 μg of NAGB. Four hours later, 37 MBq of either ¹⁷⁷Lu- or ⁹⁰Y-labeled DOTA-biotin was administered. The control group received no injections. (WBC (A) and PLT (B) counts ± SD; n = 10).