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. 2015 Mar 18;10(3):e0120561. doi: 10.1371/journal.pone.0120561

Table 2. Mean radiation absorbed doses from radiolabeled DOTA-biotin in Ramos-xenografted mice pretargeted with 1F5-SA.

	¹⁷⁷Lu-DOTA-Biotin			⁹⁰Y-DOTA-Biotin
Tissue	Gy/MBq	Gy/37 MBq	TNTDR ^a	Gy/MBq	Gy/37 MBq	TNTDR ^a
Blood	0.066	2.4	9.4	0.108	4.0	12.4
Lung	0.043	1.6	14.5	0.213	7.9	6.3
Liver	0.072	2.7	8.6	0.180	6.7	7.5
Spleen	0.043	1.6	14.5	0.154	5.7	8.7
Stomach	0.023	0.9	27.0	0.037	1.4	36.3
Kidney	0.275	10.2	2.3	0.348	12.9	3.9
Small intestine	0.019	0.7	32.7	0.039	1.4	34.4
Large intestine	0.060	2.2	10.4	0.161	6.0	8.3
Muscle	0.011	0.4	56.5	0.056	2.1	24.0
Femur	0.015	0.6	41.5	0.028	1.0	48.0
Tail	0.039	1.4	15.9	0.036	1.3	37.3
Carcass	0.027	1.0	23.0	0.069	2.6	19.5
Tumor	0.622	23.0		1.343	49.7

^aTNTDR = Tumor-to-normal tissue dose ratio

n = 5 per treatment and time point (4, 24, 48, and 120 hours p.i.)