Table 3. Changes in biochemical parameters after aspartame and control preparation in aspartame sensitive and non-sensitive group.
| Parameter | ||||||||
|---|---|---|---|---|---|---|---|---|
| Group | Sensitive | Sensitive | Control | Control | ||||
| Treatment | Pre-aspartame | Post-aspartame | Pre-control | Post-control | Pre-aspartame | Post-aspartame | Pre-control | Post-control |
| Mean ± SEM | Mean ± SEM | Mean ± SEM | Mean ± SEM | Mean ± SEM | Mean ± SEM | Mean ± SEM | Mean ± SEM | |
| Glucose (mmol/L) | 5.70 ± 0.24 | 6.19 ± 0.46 | 5.78 ± 0.31 | 6.32 ± 0.48 | 5.30 ± 0.21 | 5.39 ± 0.22 | 5.32 ± 0.23 | 5.51 ± 0.31 |
| Insulin (μIU/mL) | 15.02 ± 2.03 | 14.89 ± 2.14 | 14.10± 2.07 | 13.30 ± 2.05 | 10.26 ± 1.13 | 9.56 ± 1.23 | 10.74 ± 1.05 | 9.18 ± 1.17 |
| HOMA_IR | 3.70 ± 0.66 | 4.51 ± 1.15 | 3.90± 0.83 | 4.34 ± 1.12 | 2.54 ± 0.39 | 2.51 ± 0.47 | 2.59 ± 0.45 | 2.72 ± 0.65 |
| TC (mmol/L) | 4.79 ± 0.19 | 4.85 ± 0.19 | 4.68 ± 0.18 | 4.76 ± 0.18 | 4.67 ± 0.18 | 4.72 ± 0.18 | 4.65 ± 0.16 | 4.65 ± 0.17 |
| Triglycerides (mmol/L) | 1.98 ± 0.22 | 1.77 ± 0.16 | 1.86 ± 0.18 | 1.77 ± 0.18 | 1.28 ± 0.09 | 1.23 ± 0.09 | 1.25 ± 0.08 | 1.23 ± 0.09 |
| LDL-C (mmol/L) | 2.79 ± 0.16 | 2.87 ± 0.16 | 2.72± 0.15 | 2.76 ± 0.14 | 2.72 ± 0.13 | 2.78 ± 0.12 | 2.73 ± 0.10 | 2.73 ± 0.11 |
| HDL-C (mmol/L) | 1.16 ± 0.05 | 1.20 ± 0.05 | 1.16 ± 0.06 | 1.19 ± 0.06 | 1.35 ± 0.08 | 1.38 ± 0.08 | 1.35 ± 0.07 | 1.35 ± 0.07 |
| GLP-1 pM | 26.66 ± 1.83 | 57.85 ± 10.31** | 30.00 ± 2.09 | 51.16 ± 8.76* | 25.95 ± 1.38 | 59.67 ± 15.22 | 25.48 ± 1.28 | 45.82 ± 7.06** |
| GIP pg/mL | 75.14 ± 3.82 | 48.28 ± 4.15*** | 75.95 ± 3.66 | 47.69 ± 3.06*** | 77.70 ± 4.19 | 49.19 ± 4.22*** | 76.98 ± 4.19 | 42.18 ± 2.77*** |
| Tyrosine μM | 76.04 ± 2.83 | 62.85 ± 2.90*** | 74.43 ± 3.09 | 62.20 ± 2.62*** | 69.85 ± 2.59 | 58.76 ± 2.23*** | 68.09 ± 2.62 | 57.01 ± 2.10*** |
| Phenylalanine μM | 82.01 ± 2.73 | 77.92 ± 2.48* | 80.74 ± 2.55 | 74.80 ± 2.06*** | 76.21 ± 2.00 | 73.63 ± 1.86 | 77.85 ± 1.67 | 72.40 ± 1.87*** |
| TP ratio | 1.11 ± 0.03 | 1.29 ±0.04 *** | 1.12 ± 0.04 | 1.26 ± 0.05*** | 1.13 ± 0.04 | 1.30 ± 0.04* | 1.19 ± 0.04 | 1.32 ± 0.04*** |
To convert values for glucose to milligrams per deciliter, divide by 0.056.
To convert values for insulin to picomoles per liter, multiply by 6.
To convert values for cholesterol to milligrams per deciliter, divide by 0.0259.
To convert values for triglycerides to milligrams per deciliter, divide by 0.0113.
TC—Total cholesterol; LDL-C—LDL-cholesterol; HDL-C—HDL cholesterol; TG-Triglycerides
GLP-1—Glucagon-like peptide-1
GIP—Glucose-dependent insulinotropic polypeptide
HOMA—Homeostasis model of assessment—insulin resistance
TP ratio—Tyrosine/Phenylalanine ratio
Mean ± SEM—Mean ± Standard error of mean
AP difference—difference between aspartame and control group
P value –
* P < 0.05
** P < 0.01
*** for P < 0.001