Fig 1. Protective efficacy of UV-4 dosing TID vs BID against influenza-infected mice.

(A) To examine the effect of UV-4 administration on the weight of healthy BALB/c mice (5 males and 5 females per group), UV-4 was given TID via oral gavage at 0, 50, 100 or 200 mg/kg for 14 days (study days 0–13). The mean weights with standard deviation for each group are plotted on the study days that they were measured. (B) Groups of mice (n = 10) received the first treatment dose of compound in water 1 h before an INFV infection with mouse-adapted influenza A/Texas/36/91 at a dose of ~1LD₉₀. Graph shows treatment with 100 or 10 mg/kg of UV-4 two or three times a day for 10 days, PO, at 12 or 8 hour increments or vehicle control given thrice daily for 10 days. Survival data is plotted as percent survival against days post infection.