Fig 4. Determination of minimal effective dose of UV-4 against mouse-adapted Tamiflu-resistant strain of influenza A/Perth/261/2009 (H275Y).

Female BALB/c mice were infected with ~1xLD₉₀ of mouse-adapted Tamiflu-resistant strain of influenza A/Perth/261/2009 (H275Y) (H1N1) via IN instillation. Mice (n = 10/group) were orally treated TID for 10 days with 200, 150, 100, 80, 60, or 40 mg/kg of UV-4 or vehicle only or twice daily for 5 days with oseltamivir phosphate at 20 mg/kg. (A) Survival data is plotted as percent survival against days post-infection. B) The mean health score for each group are plotted against days post infection. C) The mean percent temperatures for each group are plotted compared to their percent temperature on day 0 (baseline) against days post infection. D) The mean percent weights for each group are plotted compared to their percent weight on day 0 (baseline) against days post infection.