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. 2014 Dec 25;14(2):209–218. doi: 10.1111/acel.12299

Figure 5.

Figure 5

Sleep–wake patterns, NREM delta power, body weight, body composition, and daily food intake in DMH-specific Prdm13-knockdown mice. (A–C) The amount of wakefulness (wake) (A), NREM sleep (NREM) (B), and REM sleep (REM) (C) in DMH-specific firefly Luciferase (fLuc)-knockdown control mice and Prdm13-knockdown mice. Numbers of bins are shown as mean values ± S.E. (*P < 0.05 by Wilcoxon matched-pairs signed-rank test, n = 5–6 mice per group). Shaded areas represent the dark periods. A gray arrow in C indicates the ZT20 time point on Day 2 when an abnormal peak was observed in Prdm13-knockdown mice (see text). (D and E) Electroencephalogram delta power in NREM sleep (D) or in wake (E). Data are shown as mean values ± S.E. (*P < 0.05, **P < 0.01 by Wilcoxon matched-pairs signed-rank test, n = 5–6 mice per group). (F–H) Body weight (F), fat mass (G), lean mass (H), and daily food intake (I) for Prdm13-knockdown mice are normalized to the average values of fLuc-knockdown control mice within each cohort (3 cohorts). Fat mass and lean mass were measured by EchoMRI. Individual data are plotted, and mean values and S.E. are shown (*P < 0.05, **P < 0.01 by Student's t-test, n = 6 mice per group).