Table 1.
Conditions that suppress or increase serum SHBG level without affecting circulating free or bioavailable testosterone level16
| Conditions that suppress serum SHBG level | Moderate obesity, type 2 diabetes, nephrotic syndrome, hypothyroidism, acromegaly, familial SHBG deficiency, and use of glucocorticoids, progestins and androgens |
| Conditions that increase serum SHBG level | Aging, hepatic cirrhosis, hepatitis, hyperthyroidism, infection with human immunodeficiency virus, and use of anticonvulsants and estrogens |
SHBG, sex hormone binding globulin.