Table 3.

Age-, sex- and body mass index-adjusted association between insulin resistance and histological scores of the liver

	Matsuda index			Hepatic insulin resistance index			MCR†
	Coefficient	t-statistic	P	Coefficient	t-statistic	P	Coefficient	t-statistic	P
Steatosis	−0.36	−3.08	0.003*	−0.60	−0.50	0.617	−0.62	−2.39	0.036*
Grade	−0.51	−5.18	<0.001*	0.20	1.91	0.061	−0.08	−0.31	0.761
Stage	−0.37	−3.47	0.001*	0.45	0.41	0.685	−0.08	−0.27	0.790
Steatosis‡	−0.22	−2.02	0.047*	−1.44	−1.19	0.237	−0.62	−2.16	0.059
Grade†	−0.40	−3.00	0.004*	0.36	2.43	0.018*	−0.02	−0.04	0.969
Stage‡	−0.07	−0.54	0.593	−0.17	−1.21	0.229	−0.05	−0.12	0.909

MCR, metabolic clearance rate. All models were adjusted for age, sex and body mass index (BMI) by multiple linear regression.

^*A P-value <0.05 is considered statistically significant.

^†A euglycemic hyperinsulinemic clamp was carried out in 16 patients.

^‡Three histological scores are included in the model.