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. 2015 Jan 19;16(3):370–378. doi: 10.15252/embr.201439264

Figure 4.

Figure 4

Reducing H3K27 or increasing H3K4 methylation prior to OSKM induction increases per-lineage reprogramming potential
  • A Schematic of inhibitors experiment. Inhibitors were added during the 48 h preceding dox induction, for either 24 or 48 h.
  • B Effect of pre-treatment with different inhibitors on reprogramming efficiency. Shown are mean and standard deviation for imaged colony counts over 6 replicate wells (see counting procedure in Materials and Methods).
  • C Fraction of lineage pairs with each corresponding fate combination after transient Ezh2 inhibition in the somatic population (left) or after no treatment (right, taken from Fig2).
  • D Time of first division for the different lineage pairs under Ezh2 pre-dox inhibition (left) or no treatment (right).