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. 2015 Mar 18;11(3):e1004068. doi: 10.1371/journal.pcbi.1004068

Fig 3. Drug candidates inhibit growth in lung cancer cell lines more than other Connectivity Map drugs.

Fig 3

We tested whether the drugs that we identified as significantly reversing the gene changes seen with lung cancer were better at inhibiting growth using NCI-60 GI50 data in 9 lung cancer cell lines. In every cell line, significant drugs are better than other Connectivity Map drugs at inhibiting growth (Wilcox test P < 0.01). On the y axis, growth inhibition is presented as-log10 GI50, so that e.g. a value of 6 corresponds to a pGI50 of 10-6 M.