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. 2015 Mar 18;10(3):e0118434. doi: 10.1371/journal.pone.0118434

Fig 6. Conventional dendritic cells are required for VLP-mediated post-exposure protection.

Fig 6

(A) SCID mice were infected with EBOV and treated with VLPs 24 hours after infection or left untreated. Little delay in time-to-death was observed with VLP treatment. n = 20, two separate experiments. (B) CD11c-DTR mice were injected with diphtheria toxin to deplete cDCs, then infected with EBOV and treated with VLP 24 hours after infection or left untreated. As a control, wild-type mice received diphtheria toxin injections and were treated with VLPs after infection. n = 9 for CD11c-DTR groups, n = 20 for WT (two separate experiments).