Table 2. Antimicrobial activity of HBD4 and the analogs.

	HBD4	H4-1d	H4-2d	H4-3d
E. coli a	5 (0.53)	2.5 (0.84)	10 (2.01)	10 (0.46)
P. aeruginosa	12 (1.35)	3 (0.11)	6.5 (1.09)	5 (0.15)
S. aureus b	15 (0.47)	3.5 (1.00)	7.5 (0.28)	6 (1.30)
C. albicans	7.5 (0.91)	5 (0.10)	10 (2.96)	12.5 (0.34)

Values (in μM) are lethal concentration (LC) against bacteria and minimum fungicidal concentration (MFC) against C. albicans. Values in parenthesis indicate standard deviation.

^a LC values for H4-1dΔEF, H4-1d[S] and H4-1d[S]ΔEF against E. coli are 2.5 μM, 3 μM and 3 μM respectively.

^b LC values for H4-1dΔEF, H4-1d[S] and H4-1d[S]ΔEF against S. aureus are 3.5 μM, 5 μM and 5 μM respectively.