Table 3.
PrP species from brain homogenates of prion-infected mice analysed by CDI after velocity centrifugation
| Mouse linea | PrPC (ng/ml) ± SEM | PrPSc (ng/ml) ± SEM | rPrPSc (ng/ml) ± SEM | PrPC/PrPSc ratio ± SEM | Incubation time (days) ± SEM |
|---|---|---|---|---|---|
| WT | 757 ± 36.0 | 1769 ± 69 | 460 ± 8.1 | 1.6 ± 0.03 | 158 ± 5 |
| TgPrP(WT) | 274 ± 5.3 | 1101 ± 39 | 323 ± 13 | 0.8 ± 0.01 | 364 ± 11 |
| TgPrP(S1)-17 | 414 ± 6 | 364 ± 18 | 110 ± 3 | 3.8 ± 0.06 | 139 ± 5 |
| TgPrP(S1)-19 | 748 ± 13 | 589 ± 12 | 153 ± 4 | 4.9 ± 0.03 | 147 ± 1 |
| TgPrP(S1)-39 | 172 ± 2.9 | 299 ± 4 | 82 ± 2 | 2.1 ± 0.01 | 411 ± 14 |
| TgPrP(S3)-35 | 1408 ± 13.7 | 288 ± 5 | 107 ± 3 | 13.1 ± 0.10 | 74 ± 1 |
| TgPrP(S3)-14 | 1816 ± 87.3 | 265 ± 8 | 94 ± 2 | 19.2 ± 0.39 | 91 ± 5 |
a
All animals were infected with the RML isolate of mouse-adapted scrapie prions.