Table 1. Characteristics of subjects without AMD, with early AMD and with any AMD.
| Demographics | All (N = 4918) a | Without AMD (N = 4626) | With Early AMD (N = 274) | With Any AMD (N = 292) | P Value b | P Value c |
|---|---|---|---|---|---|---|
| Age (yrs) | 58.54 (10.45) | 58.07 (10.28) | 66.02 (10.31) | 66.1 (10.27) | <0.001 | <0.001 |
| Female | 2441 (49.63) | 2332 (50.41) | 105 (38.32) | 109 (37.33) | <0.001 | <0.001 |
| Current smokers | 872 (17.76) | 828 (17.92) | 39 (14.34) | 44 (15.17) | 0.133 | 0.235 |
| Hypertension | 3097 (63.23) | 2863 (62.16) | 217 (79.20) | 234 (80.14) | <0.001 | <0.001 |
| Diabetes | 1395 (28.69) | 1304 (28.51) | 86 (31.73) | 91 (31.49) | 0.254 | 0.278 |
| Hyperlipidaemia | 2119 (43.63) | 1976 (43.25) | 134 (49.63) | 143 (49.65) | 0.040 | 0.034 |
| Chronic kidney disease | 761 (15.48) | 688 (14.88) | 69 (25.18) | 73 (25.00) | <0.001 | <0.001 |
| CFH rs10801555 | ||||||
| GG | 3333 (67.77) | 3144 (67.96) | 180 (65.59) | 189 (64.73) | ||
| GA | 1357 (27.59) | 1276 (27.58) | 75 (27.37) | 81 (27.74) | 0.160 | 0.049 |
| AA | 228 (4.64) | 206 (4.45) | 19 (6.93) | 22 (7.53) | ||
| ARMS2 rs3750847 | ||||||
| CC | 1992 (40.50) | 1885 (40.75) | 103 (37.59) | 107 (36.53) | ||
| CT | 2257 (45.89) | 2133 (46.11) | 111 (40.51) | 124 (42.47) | <0.001 | <0.001 |
| TT | 669 (13.60) | 608 (13.14) | 60 (21.90) | 61 (20.89) |
Data presented are no. (%), except for age, which is presented as mean (SD). Analysis was done by individual level.
a Number of subjects with missing data for the following variables: current smokers, 8; hypertension, 20; diabetes, 55; hyperlipidaemia, 61; chronic kidney disease, 1.
b For comparison between individuals without AMD vs with early AMD, using chi-square tests for categorical variables, and two sample t-tests for continuous variables.
c For comparison between individuals without AMD vs with any AMD, using chi-square tests for categorical variables, and two sample t-tests for continuous variables.