Table 2. Distribution of AMD and cataract surgeries by ethnicity.
| Total (N = 9529 Eyes) | Malays (N = 4675 Eyes) | Indians (N = 4854 Eyes) | P Value a | |
|---|---|---|---|---|
| Early AMD | 346 (3.63) | 159 (3.41) | 187 (3.86) | 0.243 |
| Late AMD | 31 (0.33) | 18 (0.40) | 13 (0.28) | 0.321 |
| Any AMD | 377 (3.96) | 177 (3.79) | 200 (4.12) | 0.403 |
| Past Cataract Surgery | ||||
| Pseudophakic | 916 (9.62) | 329 (7.04) | 587 (12.10) | |
| Aphakic | 9 (0.09) | 5 (0.11) | 4 (0.08) | |
| Total | 925 (9.71) | 334 (7.14) | 591 (12.18) | <0.001 |
Data presented are no. (%). Analysis was done on eye level.
a P values are for 2x2 comparisons between variable of interest (yes/no) and ethnicity (malays/indians), 1 degree of freedom chi-square test. Pseudophakic/aphakic eyes were more likely have early AMD (9.1%) or any AMD (9.3%), compared to phakic eyes (3.0% and 3.4% with early and any AMD, respectively, both p <0.001, Table 3). In the univariate analysis, the ARMS2 (rs3750847) genotype was significantly associated with early AMD and any AMD (both p <0.001), while the CFH (rs10801555) genotype had marginally significant association with any AMD (p = 0.049) but not with early AMD (p = 0.160, Table 1).