Table 4. Multivariate analysis showing the association of AMD with lens status, and the CFH and ARMS2 SNPs.
| Early | AMD | Any | AMD | |||||
|---|---|---|---|---|---|---|---|---|
| Model 1 a (N = 9498) | Model 2 b (N = 9269) | Model 1 a (N = 9529) | Model 2 b (N = 9300) | |||||
| OR (95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) | P Value | |
| Lens status | ||||||||
| Phakic | [Reference] | [Reference] | [Reference] | [Reference] | ||||
| Pseudophakic/Aphakic | 1.29 (0.95–1.77) | 0.108 | 1.36 (0.99–1.87) | 0.058 | 1.16 (0.85–1.57) | 0.349 | 1.21 (0.89–1.66) | 0.225 |
| CFH rs10801555 | ||||||||
| GG | [Reference] | [Reference] | [Reference] | [Reference] | ||||
| GA | 1.10 (0.88–1.37) | 0.421 | 1.09 (0.86–1.37) | 0.478 | 1.17 (0.94–1.45) | 0.160 | 1.16 (0.93–1.44) | 0.187 |
| AA | 1.20 (0.77–1.88) | 1.18 (0.75–1.87) | 1.36 (0.89–2.09) | 1.34 (0.87–2.08) | ||||
| ARMS2 rs3750847 | ||||||||
| CC | [Reference] | [Reference] | [Reference] | [Reference] | ||||
| CT | 1.32 (1.11–1.58) | 0.002 | 1.37 (1.14–1.64) | 0.001 | 1.33 (1.12–1.58) | 0.001 | 1.37 (1.15–1.63) | <0.001 |
| TT | 1.75 (1.23–2.51) | 1.86 (1.30–2.68) | 1.77 (1.25–2.50) | 1.88 (1.32–2.67) |
OR, odds ratio; CI, confidence interval.
aMultivariate logistic regression using general estimating equations, adjusted for age, gender, and ethnicity for the effect of lens status, and additionally adjusted for the first 5 genetic principal components for the effects of SNPs.
bAdjusted for the covariates in Model 1 and current smoker, hypertension, diabetes, hyperlipidaemia, and chronic kidney disease.