Table 5. Joint effects of lens status and CFH/ARMS2 SNP on risk of early AMD and any AMD.
| Early AMD, | OR a (95% CI) | Any AMD, | OR a (95% CI) | |
|---|---|---|---|---|
| Phakic Eyes (N = 8,575) | Pseudophakic/Aphakic Eyes (N = 923) | Phakic Eyes (N = 8,604) | Pseudophakic/Aphakic Eyes (N = 925) | |
| CFH rs10801555 | ||||
| GG | [Reference] | 1.02 (0.69–1.51) | [Reference] | 0.97 (0.66–1.42) |
| GA | 0.95 (0.73–1.25) | 1.57 (1.07–2.29) b | 1.06 (0.82–1.36) | 1.46 (1.00–2.12) |
| AA | 0.91 (0.53–1.55) | 2.40 (1.25–4.61) c | 1.12 (0.68–1.85) | 2.19 (1.14–4.20) b |
| P value for interaction d | 0.037 | 0.115 | ||
| ARMS2 rs3750847 | ||||
| CC | [Reference] | 1.15 (0.72–1.82) | [Reference] | 1.05 (0.67–1.66) |
| CT | 1.28 (1.04–1.57) b | 1.69 (1.18–2.42) c | 1.30 (1.07–1.58) c | 1.53 (1.08–2.18) b |
| TT | 1.64 (1.09–2.46) b | 2.48 (1.44–4.27) c | 1.68 (1.14–2.49) c | 2.23 (1.30–3.81) c |
| P value for interaction d | 0.495 | 0.570 |
OR, odds ratio; CI, confidence interval.
a Odds ratios were calculated using multivariate logistic regression using general estimating equations, adjusted for age, gender and the first 5 genetic principal components.
b P <0.05
c P <0.01
d P-value of the interaction term βGE GE was used to assess the significance of the interaction between lens status and genetic variants.