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. 2015 Mar 18;10(3):e0118605. doi: 10.1371/journal.pone.0118605

Fig 5. Tracings showing (A) Spasmogenic effect of Pyrus pashia (Pp.Cr) in concentration dependent manner on spontaneously contracting isolated rabbit aortic tissue.

Fig 5

Further, pretreatment of aortic tissue with each 1μM of cyproheptadine (B) and phentolamine (C) significantly inhibited the spasmogenic effect of Pp.Cr. When isolated aortic tissue was pre-contracted with phenylephrine (PE: 1μM)- and high K+ (80 mM), Pyrus pashia (Pp.Cr) exhibited concentration dependent vasodilator effect against high K+ while ineffective against phenylephrine (D). Values are the mean ± SEM, n = 5.