Table 2. Hazard ratios for all-cause and cardiovascular mortality according to serum MCP-1levels.
| Baseline serum MCP-1 level | P trend | |||
|---|---|---|---|---|
| <33.3% | 33.3 to <66.7% | ≥66.7 | ||
| No. of subjects | 470 | 468 | 473 | |
| Person-years | 1477 | 1586 | 1602 | |
| All-cause mortality | ||||
| No. of death | 33 | 27 | 57 | |
| Adjustment for age and gender | 1.42 (0.86–2.37) | 1.00 | 1.98 (1.25–3.14) | 0.01 |
| Multivariable adjustment* | ||||
| Model 1* | 1.46 (0.87–2.43) | 1.00 | 2.01 (1.27–3.19) | 0.01 |
| Model 2 † | 1.61 (0.95–2.72) | 1.00 | 2.12 (1.31–3.42) | 0.009 |
| Model 3 ‡ | 1.51 (0.89–2.58) | 1.00 | 2.11 (1.31–3.40) | 0.01 |
| Cardiovascular mortality | ||||
| No. of death | 24 | 19 | 45 | |
| Adjustment for age and gender | 1.46 (0.80–2.66) | 1.00 | 2.23 (1.30–3.81) | 0.01 |
| Multivariable adjustment* | ||||
| Model 1* | 1.52 (0.83–2.79) | 1.00 | 2.27 (1.32–3.90) | 0.01 |
| Model 2 † | 1.56 (0.84–2.92) | 1.00 | 2.23 (1.27–3.89) | 0.02 |
| Model 3 ‡ | 1.50 (0.80–2.81) | 1.00 | 2.21 (1.27–3.87) | 0.02 |
*Model 1 was adjusted for age, gender, education, leisure-time physical activity, smoking, and alcohol drinking.
†Model 2 was adjusted for model 1 covariates plus history of heart failure, body mass index, systolic blood pressure, fasting plasma glucose, low-density lipoprotein cholesterol, glomerular filtration rate, use of antihypertensive, anti-diabetic, cholesterol-lowering, and anti-platelet drugs.
‡ Model 3 was adjusted for model 2 covariates plus C-reactive protein.
MCP-1, monocyte chemoattractant protein-1.