Fig. 3.
GAS vaccine peptide amphiphile micelles induced strong antibody isotype responses in vivo. Only mice given the J8-diC16 vaccine produced appreciable IgM titers. Mice given J8 + KLIP in IFA or J8-diC16 vaccines produced similar quantities of IgG antibody that directly correlated to the number of vaccinations. In contrast, no antibody titers were observed for J8 + diC16-SK4-vaccinated mice. While IgA titers were assessed, no mouse produced above background levels. Each point represents one mouse (N = 6); bars represent the mean. Within a graph, groups that possess different letters have statistically significant differences in mean (p ≤ 0.05) whereas those that possess the same letter are similar (p > 0.05)