Table III.

Mean ± SD Pharmacokinetic Parameters of ABT-639 Following Multiple Doses

		Part III, healthy adults				Part IV, elderly subjects
Pharmacokinetic parameters	Units	10 mg BID (N = 9)	40 mg BID (N = 9)	100 mg BID (N = 9)	160 mg BID (N = 9)	40 mg BID (N = 9)	160 mg BID (N = 9)
		Day 7			Day 14	Day 7
C max	ng/mL	598 ± 204	2,070 ± 242	5,140 ± 968	7,370 ± 1,650	2,270 ± 713	8,620 ± 1,790
T max	h	2.56 ± 0.53	2.44 ± 0.53	2.83 ± 0.50	2.17 ± 0.66	2.25 ± 0.65	1.88 ± 0.58
C trough	ng/mL	151 ± 80	494 ± 210	1,080 ± 502	1,240 ± 520	693 ± 606	1,610 ± 608
AUC0–12 a	μg·h/mL	3.97 ± 1.5	13.5 ± 3.1	30.7 ± 8.3	42.5 ± 11.8	15.9 ± 8.2	52.0 ± 13.6
AUC12–24 a	μg·h/mL	3.45 ± 1.40	11.9 ± 2.8	26.6 ± 7.5	39.7 ± 9.7	14.7 ± 7.7	46.7 ± 10.8
CL/F	L/h	2.82 ± 0.98	3.10 ± 0.64	3.46 ± 0.86	4.04 ± 1.17	2.94 ± 0.95	3.28 ± 0.91
t ½ b	h	5.52 ± 1.2	5.80 ± 1.7	6.56 ± 1.5	6.44 ± 2.24	7.40 ± 2.32	8.77 ± 2.91
AUC R ac c		1.36 [1.13–1.75]	1.12 [1.07–1.45]	1.16 [1.02–1.47]	1.23 [1.08–1.40]	1.25 [1.10–1.60]	1.13 [0.97–1.29]

Mean ± standard deviation reported

^aAUC value on study day 7

^bHarmonic mean and pseudo standard deviation

^cMedian (range)