Table 3.

Patient-reported tools used to assess peripheral neuropathy in clinical trials

Measure	Description
FACT/GOG-Ntx subscale [73, 74, 77, 92]	11-Item neurotoxicity subscale of FACT-General
	Scoring: 0–4, with 0 representing “not at all” and 4 representing “very much”
	Example item: I feel discomfort in my hands.
QLQ-CIPN20 [80]	20-Item self-report questionnaire designed to supplement the EORTC Quality Of Life Questionnaire
	Scoring: 1–4, with 1 representing “not at all” and 4 representing “very much.”
	Example item: during the past week, did you have tingling toes or feet?
Chemotherapy-Induced Peripheral Neuropathy Tool [79]	50-Item self-report questionnaire
	Scoring: 0–10, with 0 representing “not at all” and “never” and 10 representing “completely,” “always,” or “extremely”
	Example item: at its worst, how severe is the numbness in the hands?
Patient Neurotoxicity Questionnaire [70]	2 Subjective items that assess sensory and motor neuropathy
	Scoring: A (no neuropathy) to E (severe neuropathy)
	Example item: I have no numbness, pain, or tingling in my hands or feet.

EORTC European Organisation for the Research and Treatment of Cancer, FACT Functional Assessment of Cancer Therapy, FACT/GOG-Ntx FACT/Gynecologic Oncology Group Neurotoxicity, QLQ-CIPN20 Quality of Life Questionnaire–Chemotherapy-Induced Peripheral Neuropathy 20