TABLE 1.

Risk of invasive candidiasis based on screening time point and anatomical site of colonization (derived from culture results only; entire patient cohort included)

Variablea	n	RRb	P value	95% confidence interval (low)	95% confidence interval (high)	Sensitivity (%)	Specificity (%)	PPVc (%)	NPVd (%)
Time point 1 (n studied = 6,015)
Any site colonized (CIe ≥ 0.3)	3,511	2.35	0.002	1.35	4.08	78	40	2	99
At least throat colonized	2,927	2.04	0.004	1.25	3.34	68	49	2	99
At least perineum colonized	1,967	1.76	0.0155	1.1	2.77	48	66	2	99
At least urine colonized	630	2.25	0.003	1.32	3.84	23	88	3	99
Time point 2 (n studied = 3,244)
Any site colonized (CI ≥ 0.3)	2,025	3.69	0.001	1.66	8.17	86	38	2	99
At least throat colonized	1,555	2.97	0.0007	1.58	5.56	74	51	2	99
At least perineum colonized	1,313	1.54	NSf	0.89	2.67	52	59	2	99
At least urine colonized	450	1.81	NS	0.95	3.44	24	85	3	99
Time point 3 (n studied = 1,820)
Any site colonized (CI ≥ 0.3)	1,162	1.41	<0.0001	1.23	1.61	89	37	2	100
At least throat colonized	837	5.04	0.001	1.93	13.21	82	53	3	99
At least perineum colonized	762	2.04	NS	0.96	4.34	61	57	2	99
At least urine colonized	284		NS

^aTime point 1, days 3 to 4 post-ICU admission; time point 2, days 6 to 8 post-ICU admission; time point 3, days 9 to 11 post-ICU admission.

^bRR, relative risk.

^cPPV, positive predictive value.

^dNPV, negative predictive value.

^eCI, colonization index.

^fNS, not significant.