TABLE 1.
Characteristics and performances of the models for the detection of P. aeruginosa high-risk clones
| Model | Training set |
Validation seta |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Total (no.) | Peak biomarkers (m/z) | Recognition capability (%) | Cross-validation (%) | Total (no.) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | |
| Cluster 1 | 6,734 | 100 | 99.86 | 92.5 | 95.9 | 87.3 | 97.6 | ||
| Cluster 1 | 11 | 9,586 | 67 | ||||||
| Other STs | 35 | 9,617 | 219 | ||||||
| 11,037 | |||||||||
| ST235b | 5,813 | 96.75 | 94.08 | 96.3 | 82.5 | 78.8 | 97.0 | ||
| ST235 | 5 | 11,611 | 27 | ||||||
| Other STs | 6 | 40 | |||||||
| ST111 | 3,657 | 100 | 99.94 | 81.8 | 98.9 | 81.8 | 99.2 | ||
| ST111 | 5 | 6,508 | 11 | ||||||
| Other STs | 41 | 8,502 | 275 | ||||||
| 10,041 | |||||||||
| 10,538 | |||||||||
| 12,579 | |||||||||
| ST175 | 5,211 | 96.86 | 84.26 | 100 | 92.6 | 41.2 | 100 | ||
| ST175 | 3 | 5,738 | 14 | ||||||
| Other STs | 43 | 7,203 | 272 | ||||||
| 7,329 | |||||||||
| 7,359 | |||||||||
| 7,580 | |||||||||
| 7,613 | |||||||||
| 12,154 | |||||||||
| ST253 | 5,813 | 99.09 | 72.5 | 100 | 97.5 | 58.8 | 100 | ||
| ST253 | 2 | 10 | |||||||
| Other STs | 44 | 276 | |||||||
| ST395 | 7,718 | 100 | 100 | 100 | 99.3 | 89.5 | 100 | ||
| ST395 | 8 | 8,550 | 17 | ||||||
| Other STs | 38 | 11,582 | 269 | ||||||
| 16,799 | |||||||||
a
PPV, positive predictive value; NPV, negative predictive value.
b
Within the isolates belonging to cluster 1 (see Fig. 1).