TABLE 1.

hrHPV detection by cobas HPV and AHPV tests overall and stratified by diagnosis^a

CIN gradeb	AHPV+	cobas+	AHPV+/cobas+	AHPV+/cobas−	AHPV−/cobas+	AHPV−/cobas−	Total no. of cases	% Agreement	% Positive agreement	Kappa	P
All								90.9	81.1	0.815	0.0004
No. of cases	414	448	386	28	62	512	988
% row	41.9	45.3	39.1	2.8	6.3	51.8
CIN3+c								92.9	92.7	0.364	1
No. of cases	40	39	38	2	1	1	42
% row	95.2	92.9	90.5	4.8	2.4	2.4
CIN2								94.2	93.5	0.767	1
No. of cases	44	45	43	1	2	6	52
% row	84.6	86.5	82.7	1.9	3.8	11.5
<CIN2								90.6	78.4	0.803	0.0003
No. of cases	330	364	305	25	59	505	894
% row	36.9	40.7	34.1	2.8	6.6	56.5

^aPaired results: positive (+) or negative (−); agreement statistics: percent agreement, percent positive agreement, and kappa value. hrHPV, high-risk human papillomavirus; AHPV, Aptima HPV. Differences in percent positive were tested for statistical significance using an exact version of the McNemar chi-square test.

^bCIN3+, cervical intraepithelial neoplasia grade 3 or worse; CIN2, cervical intraepithelial neoplasia grade 2; % row, row percentage.

^cIncludes one case of adenocarcinoma in situ.